What you need to know about the study on life and health
Posted On July 13, 2021
In a report published online Monday, researchers at the University of Michigan’s Center for Aging Research found that people with the highest levels of stress and low socioeconomic status (SES) tended to have the lowest levels of the key stress-reducing molecules known as interleukin-12 (IL-12).
These molecules are thought to protect against inflammation and inflammation-related diseases.
These findings were published in the journal PLOS One.
In other words, people who live in the most stressful environments tend to be the ones with the lowest rates of inflammation.
It is unclear why the people with high levels of IL-12 are at greater risk for the disease, but the researchers theorize that it may be because these individuals have been exposed to more stressors over time.
“We know that high levels are associated with increased risk of heart disease and cancer.
This could be because the high levels lead to inflammation,” said study co-author Sarah E. Regan, a professor of psychology and human development at the U-M School of Social Work.
“The key to preventing this disease is to make people healthier and feel better.
We need to find a way to make these molecules more effective.”
The researchers conducted two separate studies to determine how much IL-13 and its metabolites, which are found in the bloodstream, are present in people with and without chronic stress and SES.
In the first study, they tested for IL-11 and IL-2 in the blood of 675 people with a history of chronic stress (either past or present), a history or current use of the drug Prozac, and an average of 20 years of SES on their census questionnaire.
In addition, they measured IL-1 and IL–12 levels and assessed how well people were doing on a number of health-related tests.
The people in each group were also followed for an average 8.6 years.
In both studies, people with higher levels of cortisol (the stress hormone) and IL1 (the inflammatory hormone) were found to have lower levels of these molecules.
The results suggest that high cortisol levels and low IL-10 levels are protective against the disease.
“I think this suggests that stress is an important factor in chronic disease, and we need to be paying more attention to stress and inflammation,” Regan said.
The researchers also found that the levels of inflammation were associated with the likelihood that a person was suffering from chronic stress, such as being chronically unemployed or on disability.
The relationship between stress and chronic illness was also examined in a second study.
In this, researchers tested the immune system of more than 2,000 people and found that those with the strongest immune systems (those with the most IL-8, IL-6, IL1, and IL2) were more likely to be diagnosed with chronic disease than those with lower immune systems, including those with a high SES (those who are on social assistance).
These findings suggest that people who have high levels and high levels but low levels of inflammatory biomarkers are more likely than others to be suffering from the disease and to have chronic disease.
The findings could have important implications for public health.
“While there are many factors that can contribute to chronic illness, there are several pathways that contribute to the development of chronic disease,” said lead study author Daniel J. Brown, a Ph.
D. candidate in psychology at the university.
“For example, people on social support are at higher risk for chronic illness.
Chronic illness in adulthood is a major contributor to mortality and morbidity.
Chronic stress can lead to immune dysfunction, which could be a cause of chronic illness.”
The findings suggest the importance of recognizing the different pathways of inflammation in health and disease.
However, it is unclear whether the inflammation-protective effects of IL1 and its metabolite, IL11, are the same for everyone.
For the latest information on aging, go to http://www.medicine.utah.edu/diet/olding.htm. “
In addition, we need more research on the effects of chronic inflammation on the immune systems of those with higher inflammation levels.”
For the latest information on aging, go to http://www.medicine.utah.edu/diet/olding.htm.
Follow Dr. David DeBolt on Twitter at http://twitter.com/davidebolt.